Interchromosomal Crossover in Human Cells Is Associated with Long Gene Conversion Tracts
نویسندگان
چکیده
منابع مشابه
Interchromosomal crossover in human cells is associated with long gene conversion tracts.
Crossovers have rarely been observed in specific association with interchromosomal gene conversion in mammalian cells. In this investigation two isogenic human B-lymphoblastoid cell lines, TI-112 and TSCER2, were used to select for I-SceI-induced gene conversions that restored function at the selectable thymidine kinase locus. Additionally, a haplotype linkage analysis methodology enabled the r...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2007
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.01852-06